{"id":1130,"date":"2022-06-05T16:08:41","date_gmt":"2022-06-05T16:08:41","guid":{"rendered":"https:\/\/bb-cal.com\/?p=1130"},"modified":"2022-06-05T16:22:58","modified_gmt":"2022-06-05T16:22:58","slug":"dfc-1220sp-including-ptws-1220-dissolution-bath","status":"publish","type":"post","link":"https:\/\/bb-cal.com\/dfc-1220sp-including-ptws-1220-dissolution-bath\/","title":{"rendered":"DFC-1220SP including PTWS 1220 Dissolution Bath"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1130\" class=\"elementor elementor-1130\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-19fa0df elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"19fa0df\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-911300d\" data-id=\"911300d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-26ac8cb elementor-hidden-mobile elementor-widget elementor-widget-heading\" data-id=\"26ac8cb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">DFC-1220SP<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a370e1b elementor-hidden-mobile elementor-widget elementor-widget-heading\" data-id=\"a370e1b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Semi-Automated Dissolution Test System<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-15af592 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"15af592\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-0ef4a23\" data-id=\"0ef4a23\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8826fb7 elementor-hidden-mobile elementor-widget elementor-widget-heading\" data-id=\"8826fb7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The offline DFC systems include a fraction collector or an auto sampler which will collect the sampled dissolution media. The semi-automated DFC-1220SP <br>system is composed of a PTWS 1220 staggered stirrer start dissolution <br>bath with built-in individual vessel centering, full tubing installation in <br>PTFE including either in-situ sampling probes or the EPE-1220 auto <br>sampling system, 2 PT-SP8 syringe pumps, and a PTFC-16 fraction <br>collector. In this configuration the sampling probes are either <br>always immersed into the media (in-situ) or removed after <br>sampling (EPE-1220 system). Both procedures are widely used.<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e711feb\" data-id=\"e711feb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3a0fcea elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3a0fcea\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d4d6a5a\" data-id=\"d4d6a5a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dfb2b40 elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-heading\" data-id=\"dfb2b40\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">DFC-1220SP<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c445fc9 elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-heading\" data-id=\"c445fc9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Semi-Automated Dissolution Test System<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4769f1b elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-heading\" data-id=\"4769f1b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The offline DFC systems include a fraction collector or an auto sampler which will collect the sampled dissolution media. The semi-automated DFC-1220SP system is composed of a PTWS 1220 staggered stirrer start dissolution bath with built-in individual vessel centering, full tubing installation in PTFE including either in-situ sampling probes or the EPE-1220 auto sampling system, 2 PT-SP8 syringe pumps, and a PTFC-16 fraction collector. In this configuration the sampling probes are either always immersed into the media (in-situ) or removed after sampling (EPE-1220 system). Both procedures are widely used.<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5e2d326 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5e2d326\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2cfd744\" data-id=\"2cfd744\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-325cb6e elementor-widget elementor-widget-text-editor\" data-id=\"325cb6e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<h4>Semi Automated Tablet Dissolution Testing<\/h4><p>Semi-automated in this case means auto sampling for a dissolution test instrument at pre-programmed times. Automating this step alone eases the dissolution job a lot. After all tablets have been dropped, the dissolution test proceeds automatically and all samples are simultaneously removed from each connected vessel. The sample is delivered into a connected fraction collector by a peristaltic-, or the PT-SP syringe pump.<\/p><p>These systems do not require any external PC software to control them (the WinDiss ARGUS dissolution software package can be used optionally). Sampling information is entered directly at the connected PTWS 1220 dissolution testing instrument. All Pharma Test tablet dissolution test instruments can be upgraded with a pump and PTFC-16 fraction collector or DSR-M sampling robot.<\/p><h4>Automated Sampling<\/h4><p>The perception of automation in dissolution testing differs greatly from user to user. The most labor intensive stage is taking samples at the specified time periods as found in the company SOP (Standard Operating Procedure). This involves the removal of 6 samples according to the USP\/EP and most other Pharmacopoeia, there is often a requirement for a fast or parallel start in most cases so that accurately timed sampling may be achieved.<\/p><p>At this point the operator must also consider either replacing the collected samples volumes in the dissolution vessels or keeping an accurate record of the volumes taken from each vessel so as to be able to calculate the true concentrations of subsequent samples. The pumps available are either peristaltic, piston pumps, or syringe pumps. The PT-SP syringe pump as well as the CAT valve-less piston pump will give first class accuracy in terms of volume removed and refilling from and back to the system when samples are taken.<\/p><p>Although the quality of the peristaltic pumps available today has vastly improved, it must be stressed that the peristaltic pump is still working with flexible tubing and should be qualified at the start of each determination to make sure that the flow rates are identical for each channel and that the tubing itself is in overall good condition. A good tip for long tubing life is to always release the pressure rollers from the tubing either overnight or whenever the system is left for extended periods of time and not in use.<\/p><h4>PT-SP Multi Syringe Pumps<\/h4><p>The PT-SP multi-syringe pump is designed specifically for parallel sample withdrawal and dosage of media from a dissolution bath into open vials inside a fraction collector. It is equipped with up to 8 replaceable 10ml high precision glass syringes. Each syringe is connected to a 3-way pinch valve for media flow control. The drive of the syringes is carried out simultaneously by a stepper motor. All syringes are rigidly connected to the common sturdy drive bar.<\/p><h4>CAT Valve Less Piston Pumps<\/h4><p>The CAT multiple piston pump units offer a more accurate solution to sample removal and transfer. Exact volumes may be transferred from the sample vessels to a fraction collector such as the PTFC-2\/8. In this way, as vessel refilling is not used, exact volumes of sample removal can be recorded for subsequent concentration calculations.<\/p><p>This system offers a more secure sampling method for non-closed loop or offline systems where the volume removed is calculated from an apparent flow rate over a fixed time period (as with peristaltic pumps).<\/p><p>This system is not dependent on pump tubing quality and is also a good alternative when active materials are known to absorb on tubing materials such as Tygon or Silicone. The CAT pump is available with 6, 8, 12 and 24 individual pump heads, also for auto media refilling.<\/p><h4>Operation Principle<\/h4><p>As soon as the samples have been inserted, the system will start its automated operation. The sampling times have been programmed via the touch screen of the PTWS 1220 dissolution bath and are saved as a specific method for subsequent tests.<\/p><p>After the start of test a command is sent from the dissolution bath to the PTFC-16 fraction collector and from there to the connected pump to start a sampling sequence. The EPE-1220 moves the sampling tubes and filter tips into the media to the selected sampling position.<\/p><p>The pump will be started to fill up and pre-flush the tubing. When all tubing is filled-up, the samples are collected into vials inside the collector dish of the PTFC-16. Depending on the system configuration, after dosing the volume will be refilled and the EPE-1220 will move back out of the dissolution vessels.<\/p><p>At the end of a cycle all tubing is emptied. The system is waiting for the next sampling time. All vials are covered during the test; the vial dish can be easily removed. Also special dishes are available for HPLC vials.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9e45f96 pics-gallery elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9e45f96\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c5e5cc3\" data-id=\"c5e5cc3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fb5cb7d gallery-spacing-custom elementor-widget elementor-widget-image-gallery\" data-id=\"fb5cb7d\" 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class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"fb5cb7d\" data-elementor-lightbox-title=\"en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTEwOCwidXJsIjoiaHR0cHM6XC9cL2JiLWNhbC5jb21cL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA2XC9lbi1kZmMtMTIwc3AtaW5jbHVkaW5nLXB0d3MtMTIwZC1kaXNzb2x1dGlvbi1iYXRoLWNhdC1waXN0b24tcHVtcC0wMDEuanBlZyIsInNsaWRlc2hvdyI6ImZiNWNiN2QifQ%3D%3D\" href='https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001.jpeg'><img loading=\"lazy\" decoding=\"async\" width=\"1147\" height=\"1043\" src=\"https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001.jpeg\" class=\"attachment-2048x2048 size-2048x2048\" alt=\"\" srcset=\"https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001.jpeg 1147w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001-300x273.jpeg 300w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001-1024x931.jpeg 1024w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001-768x698.jpeg 768w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001-920x837.jpeg 920w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001-230x209.jpeg 230w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-cat-piston-pump-001-350x318.jpeg 350w, 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loading=\"lazy\" decoding=\"async\" width=\"1183\" height=\"783\" src=\"https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-ptag-38-03815-ptfc-2-vial-dish-001.jpeg\" class=\"attachment-2048x2048 size-2048x2048\" alt=\"\" srcset=\"https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-ptag-38-03815-ptfc-2-vial-dish-001.jpeg 1183w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-ptag-38-03815-ptfc-2-vial-dish-001-300x199.jpeg 300w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-ptag-38-03815-ptfc-2-vial-dish-001-1024x678.jpeg 1024w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-ptag-38-03815-ptfc-2-vial-dish-001-768x508.jpeg 768w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-ptag-38-03815-ptfc-2-vial-dish-001-920x609.jpeg 920w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-ptag-38-03815-ptfc-2-vial-dish-001-230x152.jpeg 230w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-ptag-38-03815-ptfc-2-vial-dish-001-350x232.jpeg 350w, https:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/en-dfc-120sp-including-ptws-120d-dissolution-bath-ptag-38-03815-ptfc-2-vial-dish-001-480x318.jpeg 480w\" sizes=\"auto, (max-width: 1183px) 100vw, 1183px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5dc8a8c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5dc8a8c\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-778a36c\" data-id=\"778a36c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dc08d8a elementor-align-center elementor-widget elementor-widget-button\" data-id=\"dc08d8a\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"http:\/\/bb-cal.com\/wp-content\/uploads\/2022\/06\/pt-dfc-1220sp-e.pdf\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-file-pdf\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Download Brochure DFC-1220SP<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Offline automated dissolution system with 12 position bath.<\/p>\n","protected":false},"author":1,"featured_media":1118,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-1130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-offline-automated-dissolution-systems"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>DFC-1220SP including PTWS 1220 Dissolution Bath | BB-Cal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bb-cal.com\/dfc-1220sp-including-ptws-1220-dissolution-bath\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DFC-1220SP including PTWS 1220 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