Design

The cell is immersed in the dissolution vessel. It is developed for the study of drug release from hydrophobic carrier preparations, such as suppositories. It encloses a small volume (max. 30ml) of inner fluid by means of a dialysis membrane. The cell itself rotates horizontally in a larger volume of test medium, which has the same pH as the inner volume. The sample is placed inside the inner cell. The rotating speed is reduced in by a factor of 4:1 using a gear. The active dissolves through the membrane into the outer phase and can be measured there using common detection technology like UV/VIS spectrocopy for example. It is proven that the PTSW-0 cell is a suitable tool to study factors which may influence the dissolution and absorption of controlled release formulations.