Tablet dissolution testing is one of the most important tests during development and manufacturing of solid dosage forms and Transdermals. Nearly all international pharmacopoeias describe a dissolution test instrument, in which at least 6 samples should be tested. The test vessel design, stirring speed range, temperature range and accuracy, stirrer design and relevant tolerances are specified.

Today the instrument operator of such instruments expects not only conformity with the pharmacopoeia description, but also easy operation and accessibility to the test vessels. This means a dissolution bath should offer both good manual access as well as automation facilities. The PT-DT70 offers both. The test vessels are placed in 2 lines (4+3) and it is easy to remove samples and refill with solvent by lifting up the drive housing or use the sampling and tablet feeding holes in the top of the instrument.

Special MDS-DT70 Manual Sampling Tools are available including disposable Syringes to make sure that the sampling position within the dissolution vessel is kept as per requirement in the USP/EP Guidelines. The instrument design uses Mono-shaft Stirrer and Stirrer Adapters which avoid to re-adjust the Stirrer Immersion Depth after Tolling exchange. All stirrers USP/EP App. 1,2, 5 and 6 have the same total length. To insert samples and withdraw solution 7 holes and guiding tubes are placed inside the top cover of the instrument.

Simply place your tablets next to the holes and introduce when ready for test start. For easy sampling use the PT-MDS Manual Sampling System which includes sampling tube – inline filter and a 10 ml. Disposable syringe. The clear-view U-shaped Plexiglas water bath offers excellent views of the samples while they are under test. Also the PT-DT70 is already equipped with all necessary interfaces to connect a sampling system for test automation. Interface for installation of a DATA-LOGGER PT-DL1 is built-in.

Operation Principle

Simply push the drive housing backwards. Free access to all vessels for filling or cleaning. The automated self-adjustment system of the vessels inside the water bath cover ensures correct positioning of the vessels with respect to the stirrer axis. All stirrers start simultaneously. The LED display will inform of the actual stirring speed and bath temperature. The stirrers will only rotate when the drive housing is in its operating position.

For automated sampling the sampling probes placed into the corresponding holes inside the upper drive cover. They are constantly placed inside the dissolution vessels. They can be added at any time to the instrument each with its own filter. A computer controlled dissolution system will be able to control all instrument parameters and record the instrument output data. The PHARMA TEST tablet dissolution instruments can be used in compliance to apparatus 1, 2, 5 and 6 of the USP <711/724>and European Pharmacopoeia <2.9.3/4>.